The official apocalypse of the Baby Boomers: A super-flu in Stephen King’s The Stand (Doubleday, 1978) transforms the world into the final battleground of good and evil.
Cormac McCarthy’s The Road (Knopf, 2006) gives us utter finality in a grim, ashen, yet strangely life-affirming world.
We don’t need nuclear war or undead plagues to destroy us in Gene Wolfe’s dark masterpiece, Book of the New Sun (Simon & Schuster, 1983). The extinction of the sun is sufficient.
Harlan Ellison’s I Have No Mouth, and I Must Scream (Galaxy, 1967) warns us of the folly of building our own gods, especially when those gods are demented, omnipotent supercomputers.
A million year-old ghost narrates the obsolescence of the human race in Kurt Vonnegut’s latter-day gem Galápagos (1985, Delacourte Press).